Vitamin B3

Niacinamide (Vitamin B3)

vitamin b3 niacinamide


Vitamin B3 (Niacin) supplementation has benefits that may extend to growth, cognition, and longevity. This is because niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels. Preliminary evidence suggests increased NAD+ levels may result in the above benefits.

Nicotinamide is the amide form of vitamin B3 that is naturally synthesized in the body with neuroprotective and anti-inflammatory effects. Experimental evidence indicates that nicotinamide can decrease age-associated cognitive impairment.

Your brain needs niacin, as a part of the coenzymes NAD and NADP, for mental energy and in order to function properly.


Niacinamide Fast Facts

  • Niacin increases NAD levels which is essential to energy production.
  • Niacinamide improves focus, cognition, and resilience to stress.
  • Nicotinamide is used in the treatment of inflammations.


Niacinamide - an active ingredient of Savvy

Main benefits for Savvy:

  • Improves energy levels and focus
  • Assists with resilience to stress and anxiety
  • Improves cognition
  • Anti inflammatory benefits
  • Improved mood and quality of life
  • Anti inflammatory properties
  • Improvement of cognitive function

 Scientifically Proven Health Benefits of Niacinamide

Scientifically proven benefits of Niacinamide


To make it easy to identify all the different studies - we will highlight them for you!  

We really hope you enjoy our many years of research when formulating Savvy...

Benefit 1: Improves energy levels and focus

Niacinamide improves energy levels and focus


Belenky, P, et al. ‘NAD+ metabolism in health and disease’ in Trends of Biochemical Sciences Review, Volume 32, Issue 1, January 2007, pp 12-19 [Link]


“Nicotinamide is part of two essential coenzymes for energy production and DNA repair – nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP)”


Hoffman, JR, et al, ‘The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students.’ in Journal of the international society of sports nutrition, Volume 7, issue 39, December 2010 [Link]


“Results indicate that acute ingestion of CRAM can maintain reaction time, and subjective feelings of focus and alertness to both visual and auditory stimuli in healthy college students following exhaustive exercise… The purpose of this study was to examine the effect of acute and prolonged (4-weeks) ingestion of a supplement designed to improve reaction time and subjective measures of alertness, energy, fatigue, and focus...CRAM; α-glycerophosphocholine, choline bitartrate, phosphatidylserine, vitamins B3, B6, and B12, folic acid, L-tyrosine, anhydrous caffeine, acetyl-L-carnitine, and naringin… Reaction time significantly declined..”


Benefit 2: Assists with resilience to stress and anxiety

Niacinamide lessens stress and anxiety


Möhler H, et al. ‘Nicotinamide is a brain constituent with benzodiazepine-like actions’ in Nature: International journal of science, Volume 278, April 1979, pp 563-565. [Link]


“We describe here the isolation and benzodiazepine-like actions of nicotinamide, a compound which might exert these actions in the brain physiologically.”


Stough, C, et al. ‘The effect of 90 day administration of a high dose vitamin B-complex on work stress.’ in Human Psychopharmacology. Volume 26, Issue 7, October 2011, pp 470-476 [Link]


Sixty participants completed the 3-month, double-blind, randomised, placebo-controlled trial in which personality, work demands, mood, anxiety and strain were assessed. ...the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. The results of the study are consistent with two previous studies examining…supplementation of a B multivitamin.”


Benefit 3: Improves cognition

Niacinamide can improve cognition



La Rue A, et al. ‘Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment.’ in The American journal of clinical nutrition, Volume 65, Issue 1, January 1997 pp 20-29 [Link


“Several significant associations (P < 0.05) were observed between cognition and concurrent vitamin status, including better abstraction performance with higher biochemical status and dietary intake of thiamine, riboflavin, niacin, and folate (rs = 0.19-0.29) and better visuospatial performance...Higher past intake of vitamins E, A, B-6, and B-12 was related to better performance on visuospatial recall and/or abstraction tests (rs = 0.19-0.28). Use of self-selected vitamin supplements was associated with better performance on a difficult visuospatial test and an abstraction test.”


Wang W and Liang B, ‘Case report of mental disorder induced by niacin deficiency.’ in Shanghai archives of psychiatry, Volume 24, Issue 6, December 2012, pp 352-354. [Link]


“The above is indicative of brain fog and even psychiatric symptoms have been associated with niacin deficiency.


Benefit 4: Anti inflammatory benefits

Niacinamide may lessen inflammation


Niren, NM, ‘Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review.’ in Cutis, Volumen 77, Issue 1, January 2006, pp 11 - 16. [Link]


“This article reviews the substantial number of reports published over the past 50 years that document the clinical utility and safety of oral and topical formulations of nicotinamide for the treatment of a variety of inflammatory skin conditions.”


Denu, J. ‘Vitamin B3 and sirtuin function’ in Trends in Biochemical Sciences research focus, Volume 30, Issue 9, September 2005, pp 479 -483  [Link]


“Inhibits the activity of sirtuins – proteins that play important roles in aging, cell death and inflammation – can decrease neurodegenerative and age-associated memory impairment”

Benefit 5: Improves mood and subjective quality of life

Niacinamide improves quality of life


Lewis, J, E. et al. ‘The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression’ in Journal of International Scholarly Research Notices Psychiatry, Volume 2013, Article ID 621453, pp 1-7. [Link]


“The Max Stress B [B1,2,3,6,12 combination]  formula showed modest improvements in mood and mental health according to the BDI, BAI, and SF-36, making our findings consistent with the prior studies. Thus, our study shows that a high quality, whole-food dietary supplement may offer an opportunity for adults with depression to improve mood symptoms and quality of life.”


Jonsson, B H, ‘Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency’ in Nutrients, Volume 10, Issue 2, February 2018, pp 134 [Link]


“When NA (Nicotinic Acid) was prescribed, the purpose was to decrease anxiety. As this effect emerged, it was easy to stop diazepam and zolpidem. However, that the effect in this patient also stabilised his mood was a surprise.”


Cornish, S and Mehl-Madrona, L, ‘The Role of Vitamins and Minerals in Psychiatry’ in Integrative Medicine Insights, Volume 3, September 2008, pp 33-42. [Link]


It is supposed that the favorable therapeutic effects of nicotinamide, nicotinic acid and their active biological form—NAD—are realized due to the mechanisms of their functioning in the nervous system, for treating schizophrenia, epilepsy and other diseases of the nervous system”.

Benefit 6: Helps to prevent cognitive decline

Morris, MC et al, ‘Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline.’ in Journal of neurology, neurosurgery, and psychiatry, Volume 75, Issue 8, August 2004, pp 1093-1099. [Link]


“Dietary niacin may protect against AD and age related cognitive decline.”