Vitamin B12 Methylcobalamin

Vitamin B12 (Methylcobalamin)


Methylcobalamin, Vitamin B12


Vitamin B12 (cobalamin) is an essential vitamin that your body needs but cannot produce - it has to make it from the food you eat or the supplements you take.

It is involved with a key role in energy formation, supporting healthy brain functioning and the central nervous system. Vitamin B12 may benefit your body in many impressive ways, such as by boosting your energy, improving your memory, supporting cognitive health, and also supporting the nervous system to deal with stress and DNA synthesis.

Vitamin B12 is found naturally in animal products, and often needs to be supplemented. However, the form of supplement is particularly important - the methylcobalamin is much better than the other form cyanocobalamin, simply due to the amount absorbed by the body.

 Vitamin B12 Fast Facts

  • Also called Cobalamin
  • Important vitamin that comes only from foods and supplements
  • Synthesizes serotonin which results in better mood
  • Increases cognitive function
  • Improves memory


Vitamin B12 is an active ingredient of Savvy



Main benefits for Savvy:

  • Improved mood and quality of life
  • Improvement of cognitive function
  • Improves memory


Scientifically-proven benefits of Vitamin B12


Health benefits of Vitamin B12 according to Science


To make it easy to identify all the different studies - we will highlight them for you!  

We really hope you enjoy our many years of research when formulating Savvy...


Benefit 1: Mood Boosting

Vitamin B12 boosts our mood


The effect of vitamin B12 on mood is not yet fully understood. However, this vitamin plays a vital role in synthesizing and metabolising serotonin, the happiness brain chemical.


Scientific Sources:

Coppen, A and Bolander-Gouaille C. ‘Treatment of depression: time to consider folic acid and vitamin B12.’ in Journal of psychopharmacology, (Oxford, England). Volume 19, Issue 1, January 2005, pp 59-65 [Link]


Both low folate and low vitamin B12 status have been found in studies of depressive patients, and an association between depression and low levels of the two vitamins is found in studies of the general population.”


Gourgeon, L, et al, ‘Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging.’ in European journal of clinical nutrition, Volume 70, Issue 3, March 2016, pp 380 - 385. [Link]


“This study provides some evidence of decreased depression risk among women with higher intakes of vitamin B6 from food, which was dependent on total energy intake, and among men with higher intakes of B12 from food, independently of energy intake.”


Penninx, BW, et al, ‘Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study.’ in The American Journal of Psychiatry, Volume 157, Issue 5, May 2000, pp 715 - 721.[Link]


“After adjustment for sociodemographic characteristics and health status, the subjects with vitamin B(12) deficiency were 2.05 times as likely to be severely depressed as were non deficient subjects...In community-dwelling older women, metabolically significant vitamin B(12)deficiency is associated with a twofold risk of severe depression.”


Murajami, K, et al. ‘Dietary Folate, Riboflavin, Vitamin B-6, and Vitamin B-12 and Depressive Symptoms in Early Adolescence: The Ryukyus Child Health Study’ in Journal of Psychosomatic Medicine, Volume 72, Issue 9, October 2010, pp 763 - 768 [Link]


“This study suggests that higher intake of dietary B vitamins, particularly folate and vitamin B-6, is independently associated with a lower prevalence of depressive symptoms in early adolescence.”


Tiemeier, H, et al, ‘Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study’ in The American Journal of Psychiatry, Volume 159, Issue 12, December 2002, pp 2099 - 2101 [Link]


“Vitamin B12 [deficiency] may be causally related to depression”


Morris, MS, et al, ‘Depression and folate status in the US Population.’ in Psychotherapy and psychosomatics, Volume 72, Issue 2, March 2003, pp 80-87. [Link]


“This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.” The above study showed that people with mid to severe depression had 17 – 27% less vitamin B12 than their healthy counterparts.”


Stough, C, et al. ‘The effect of 90 day administration of a high dose vitamin B-complex on work stress.’ in Human Psychopharmacology. Volume 26, Issue 7, October 2011, pp 470-476. [Link]


Sixty participants completed the 3-month, double-blind, randomised, placebo-controlled trial in which personality, work demands, mood, anxiety and strain were assessed. ...the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. The results of the study are consistent with two previous studies examining…supplementation of a B multivitamin.”


Kennedy, David O. et al. ‘Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males’ in Journal of psychopharmacology. Volume 211, Issue 1, July 2010, pp 55-68. [Link]


“Healthy members of the general population may benefit from augmented levels of vitamins/minerals via direct dietary supplementation. Specifically, supplementation led to improved ratings of stress, mental health and vigour and improved cognitive performance during intense mental processing.”


Lewis, J, E. et al. ‘The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression’ in Journal of International Scholarly Research Notices Psychiatry, Volume 2013, Article ID 621453, pp 1-7. [Link]


“The Max Stress B [B1,2,3,6,12 combination]  formula showed modest improvements in mood and mental health according to the BDI, BAI, and SF-36, making our findings consistent with the prior studies. Thus, our study shows that a high quality, whole-food dietary supplement may offer an opportunity for adults with depression to improve mood symptoms and quality of life.”


Almeida OP, et al. ‘B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial.’ in The British journal of psychiatry: the journal of mental science, Volume 205, Issue 6, December 2014, pp 450-457. [Link]


“B vitamins did not increase the 12-week efficacy of antidepressant treatment, but enhanced and sustained antidepressant response over 1 year. Replication of these findings would mandate that treatment guidelines adopt the adjunctive use of B vitamins as a safe and inexpensive strategy to manage major depression in middle-aged and older adults.”


Kate, N, et al. ‘Does B12 Deficiency Lead to Lack of Treatment Response to Conventional Antidepressants?’ in Psychiatry (Edgmont), Volume 7, Issue 11, November 2010, pp 42-44 [Link]


“In this case series, the symptoms of depression and cognitive dysfunction improved with vitamin B12 supplementation”


Benefit 2: Improves cognitive function

Vitamin b12 improves cognitive function


Tangney, C. et al. ‘Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination.’ in Neurology, Volume 77, Issue 13, September 2011, pp 1276-1282. [Link]


Concentrations of all vitamin B12-related markers, but not serum vitamin B12 itself, were associated with global cognitive function and with total brain volume.”


Hoffman, JR, et al, ‘The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students.’ in Journal of the international society of sports nutrition, Volume 7, issue 39, December 2010 [Link]


“Results indicate that acute ingestion of CRAM [α-glycerophosphocholine, choline bitartrate, phosphatidylserine, vitamins B3, B6, and B12, folic acid, L-tyrosine, anhydrous caffeine, acetyl-L-carnitine, and naringin] can maintain reaction time, and subjective feelings of focus and alertness to both visual and auditory stimuli in healthy college students… Reaction time significantly declined..”


Kennedy, D. ‘B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review’ in Nutrients, Volume 8, Issue 2, 2016, pp 68 [Link]


“This review describes the closely inter-related functions of the eight B-vitamins and marshals evidence suggesting that adequate levels of all members of this group of micronutrients are essential for optimal physiological and neurological functioning.”


Smith, D and Refsum, H. ‘Vitamin B-12 and cognition in the elderly’ in The American Journal of Clinical Nutrition, Volume 89, Issue 2, February 2009, pp 707 - 711. [Link]


“Vitamin B-12 deficiency is often associated with cognitive deficits. Here we review evidence that cognition in the elderly may also be adversely affected at concentrations of vitamin B-12 above the traditional cutoffs for deficiency.”


Gewa, CA, et al. ‘Dietary micronutrients are associated with higher cognitive function gains among primary school children in rural Kenya.’ in The British journal of nutrition, Volume 101, Issue 9, May 2009, pp 1378-1387 [Link]


“...vitamin B12 and riboflavin showed significant relationships with improved cognitive test scores, after controlling for confounders such as energy intake, school, socio-economic status and morbidity….vitamin B12 and riboflavin intakes were each associated with significantly higher gains in digit span-forward test scores over time. This analysis demonstrates the influence of improved dietary micronutrient status on school children's cognitive function.”


La Rue A, et al. ‘Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment.’ in The American journal of clinical nutrition, Volume 65, Issue 1, January 1997 pp 20-29 [Link]


“Several significant associations (P < 0.05) were observed between cognition and concurrent vitamin status, including better abstraction performance with higher biochemical status and dietary intake of thiamine, riboflavin, niacin, and folate (rs = 0.19-0.29) and better visuospatial performance...Higher past intake of vitamins E, A, B-6, and B-12 was related to better performance on visuospatial recall and/or abstraction tests (rs = 0.19-0.28). Use of self-selected vitamin supplements was associated with better performance on a difficult visuospatial test and an abstraction test.”


Kennedy, D, ‘B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review’ in Nutrients, Volume 8, Issue 2, 2016. [Link]


“A further crumb of comfort was also provided by a recent meta-analysis of 10 studies involving supplementation with folic acid, plus vitamin B12 (four studies) and vitamin B6 (three studies) and a single study of vitamin B12 monotherapy, and depression in sufferers of mood disorders...the subset of three studies that assessed relapse or prevention demonstrated significant benefits for B vitamin treatment


Benefit 3: Improves Memory

Vitamin B12 improves memory


Douaud, G. et al. ‘Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment’ in Proceedings of the National Academy of Sciences of the United States of America, Volume 110, Issue 23, June 2013, pp 9523-9528 [Link]


“Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline. “


Rathod, R, et al. ‘Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function’ in Journal of Biomedical Science, Volume 23, Issue 17, 2016. [Link]


“It has been suggested that the deficiencies of both vitamin B12 and omega-3 fatty acids can have adverse effects on cognition and synaptic plasticity...Vitamin B12 is known to have fundamental roles in the brain function at all ages and also in the prevention of disorders of CNS development, mood disorders”