Vitamin B2

Riboflavin (Vitamin B2)


Riboflavin (Vitamin b2)



Vitamin B2 (Riboflavin) is a vitamin that plays an integral role in the body working with other micronutrients helping to keep you feeling your best.

It is known to help your body in its resilience to physical and mental stress while being essential for energy production. Vitamin B2 and the other B vitamins help your body build red blood cells and support other cellular functions that give you energy, improve mood and the subjective quality of life.


 Riboflavin Fast Facts

  • Riboflavin is essential for energy production.
  • Improves resilience to stress and quality of life
  • Riboflavin has anti-inflammatory properties.
  • Intake of Vitamin B2 is related to better cognitive performance.


vitamin b2


Main benefits for Savvy:

  • Improved resilience to stress
  • Improved mood and quality of life
  • Anti inflammatory properties
  • Improvement of cognitive function


Scientific Benefits of Vitamin b2

To make it easy to identify all the different studies - we will highlight them for you!

We really hope you enjoy our many years of research when formulating Savvy...

Benefit 1: Improved resilience to stress

Riboflavin helps reduce stress


Stough, C, et al. ‘The effect of 90 day administration of a high dose vitamin B-complex on work stress.’ in Human Psychopharmacology. Volume 26, Issue 7, October 2011, pp 470-476. [Link]


Sixty participants completed the 3-month, double-blind, randomised, placebo-controlled trial in which personality, work demands, mood, anxiety and strain were assessed. ...the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. The results of the study are consistent with two previous studies examining…supplementation of a B multivitamin.”


Benefit 2: Improved mood and quality of life

Riboflavin improves quality of life and mood


Murajami, K, et al. ‘Dietary Folate, Riboflavin, Vitamin B-6, and Vitamin B-12 and Depressive Symptoms in Early Adolescence: The Ryukyus Child Health Study’ in Journal of Psychosomatic Medicine, Volume 72, Issue 9, October 2010, pp 763 - 768 [Link]


“This study suggests that higher intake of dietary B vitamins, particularly folate and vitamin B-6, is independently associated with a lower prevalence of depressive symptoms in early adolescence.”


Lewis, J, E. et al. ‘The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression’ in Journal of International Scholarly Research Notices Psychiatry, Volume 2013, Article ID 621453, pp 1-7. [Link]


“B1,2,3,6,12 combination formula showed modest improvements in mood and mental health...dietary supplement may offer an opportunity for adults with depression to improve mood symptoms and quality of life.”


Kennedy, David O. et al. ‘Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males’ in Journal of psychopharmacology. Volume 211, Issue 1, July 2010, pp 55-68 [Link]


“Healthy members of the general population may benefit from augmented levels of vitamins/minerals via direct dietary supplementation. Specifically, supplementation led to improved ratings of stress, mental health and vigour and improved cognitive performance during intense mental processing.”


Bell, IR, et al. ‘Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.’ in Journal of the American College of Nutrition. Volume 11, Issue 2, April 1992, pp 159-163. [Link]


“This was a 4-week randomized placebo-controlled double-blind study to assess augmentation of open tricyclic antidepressant treatment with 10 mg each of vitamins B1, B2, and B6 in 14 geriatric inpatients with depression. The active vitamin group demonstrated significantly better B2 and B6 status on enzyme activity coefficients and trends toward greater improvement in scores on ratings of depression and cognitive function”


Miyake, Y, et al. ‘Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study.’ in Journal of affective disorders, Volume 96, Issue 1 and 2, November 2006, pp 133 - 138. [Link]


“Our results suggest that moderate consumption of riboflavin may be protective against postpartum depression.”


Benefit 3: Anti inflammatory properties


Riboflavin has anti inflammatory properties


Bertollo, CM, et al. ‘Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models.’ in European journal of pharmacology, Volume 547, Issues 1-3, October 2006, pp 184-191 [Link]


“Riboflavin, similar to other vitamins of the B complex, presents anti-inflammatory activity”


Mazur-Bialy A and Pochec, E. ‘HMGB1 Inhibition During Zymosan-Induced Inflammation: The Potential Therapeutic Action of Riboflavin.’ in Archivum immunologiae et therapiae experimentalis. Volume 64, Issue 2, April 2016, pp 171 - 176. [Link]


“One of the factors responsible for the excessive intensification of the inflammatory response in the course of inflammation is high-mobility group protein B1 (HMGB1)...The research showed that riboflavin significantly reduces both the expression and the release of HMGB1”


Benefit 4: Improvement of cognitive function


Riboflavin improves cognitive function


Gewa, CA, et al. ‘Dietary micronutrients are associated with higher cognitive function gains among primary school children in rural Kenya.’ in The British journal of nutrition, Volume 101, Issue 9, May 2009, pp 1378-1387 [Link]


“...vitamin B12 and riboflavin showed significant relationships with improved cognitive test scores, after controlling for confounders such as energy intake, school, socio-economic status and morbidity….vitamin B12 and riboflavin intakes were each associated with significantly higher gains in digit span-forward test scores over time. This analysis demonstrates the influence of improved dietary micronutrient status on school children's cognitive function.”


La Rue A, et al. ‘Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment.’ in The American journal of clinical nutrition, Volume 65, Issue 1, January 1997 pp 20-29 [Link]


“Several significant associations (P < 0.05) were observed between cognition and concurrent vitamin status, including better abstraction performance with higher biochemical status and dietary intake of thiamine, riboflavin, niacin, and folate (rs = 0.19-0.29) and better visuospatial performance...Higher past intake of vitamins E, A, B-6, and B-12 was related to better performance on visuospatial recall and/or abstraction tests (rs = 0.19-0.28). Use of self-selected vitamin supplements was associated with better performance on a difficult visuospatial test and an abstraction test.”